Which sign is NOT typically associated with Extrapyramidal Symptoms (EPS)?

Extrapyramidal Symptoms (EPS) are drug-induced movement disorders that can include a variety of movement abnormalities. Among these, tremors, consistent movement of the legs, and the specific motion known as "pill rolling" (which refers to a circular motion of the fingers that mimics rolling a small object) are commonly associated with EPS.

Tremors are a classic symptom of EPS, often presenting as resting tremors which are most noticeable when the individual is at rest. Constant movement of the legs can reflect akathisia, a form of EPS characterized by a feeling of inner restlessness and an uncontrollable need to be in constant motion. Pill rolling is specifically tied to the type of tremor seen in conditions like Parkinson's disease and is considered a hallmark of parkinsonian symptoms, frequently seen in EPS.

Headaches, however, are not typically associated with EPS. While individuals experiencing EPS may report discomfort and tension, headaches do not fit the specific movement disorder spectrum that defines EPS symptoms. Therefore, in the context of the provided options, headaches are unrelated to the typical manifestations of EPS.